Abstract
Prenatal maternal distress predicts altered offspring immune outcomes, potentially via altered epigenetics. The role of different kinds of prenatal maternal distress on DNA methylation profiles is not understood. A sample of 117 women (APrON cohort) were followed from pregnancy to the postpartum period. Maternal distress (depressive symptoms, pregnancy-specific anxiety, stressful life events) were assessed mid-pregnancy, late-pregnancy, and 3-months postpartum. DNA methylation profiles were obtained from 3-month-old blood samples. Principal component analysis identified two epigenetic components, characterized as Immune Signaling and DNA Transcription through gene network analysis. Covariates were maternal demographics, pre-pregnancy body mass index, child sex, birth gestational age, and postpartum maternal distress. Penalized regression (LASSO) models were used. Late-pregnancy stressful life events, b=0.006, early-pregnancy depressive symptoms, b=0.027, late-pregnancy depressive symptoms, b=0.014, and pregnancy-specific anxiety during late pregnancy, b=-0.631, were predictive of the Immune Signaling component, suggesting that these aspects of maternal distress could affect methylation in offspring immune signaling pathways. Only early-pregnancy depressive symptoms was predictive of the DNA Transcription component, b=-0.0004, suggesting that this aspect of maternal distress is implicated in methylation of offspring DNA transcription pathways. Exposure timing and kind of prenatal maternal distress could matter in the prediction of infant immune epigenetic profiles.
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