Prenatal genetic testing by amniocentesis appears to result in a lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection

Abstract

ObjectiveTo compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI). DesignRetrospective analysis. SettingTertiary referral center. Patient(s)Eight hundred twenty-eight patients with singleton gestations achieved by ICSI. Intervention(s)Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients). Main outcome measure(s)Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight. Result(s)A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 g (8.2% vs. 4.6%, respectively). Conclusion(s)Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI.