Prenatal exposures to mixtures of endocrine disrupting chemicals and children’s growth up to six years of age in the SELMA study

Abstract

PDS 71: Exposome, Johan Friso Foyer, Floor 1, August 27, 2019, 4:30 PM - 5:30 PM Background: Great variations in growth rate occur during pregnancy and childhood and each child follows an individual growth trajectory. However, it is not well-known how prenatal exposures to endocrine disrupting chemicals (EDCs), and especially their concurrent and combined mixture effect may impact children’s pre- and postnatal growth. Therefore, the aim of this study was to evaluate the effect of EDCs mixtures on birth weight and growth trajectories. Methods: We used data from 429 mother-child pairs participating in the Swedish Environmental Longitudinal Mother and child Asthma and allergy (SELMA) study with data on 41 EDCs, measured in urine/serum in median week 10 of pregnancy, and growth measures. Children’s weight trajectories from birth to 5.5 years of age were individually modeled using double logistic regression to estimate growth indicators; infant peak weight velocity (PWV) and age at infant PWV. The EDCs mixtures effect was modeled with birthweight and each growth indicator using a weighted quantile sum (WQS) regression model. Results: We found that increase of one decile in the WQS index of the EDC mixture was significantly associated with 91.07 (SD: 20.94) grams decrease in birth weight, and 0.27 (SD: 0.10) months later PWV. This adjusted for maternal smoke exposure, weight, age, education, parity, fish consumption and urinary creatinine as well as child’s sex and gestational age at birth. PCB-74, PBA, and MBzP, 2OH-PH, MEP, PFOA and MEHP were identified as bad actors for decrease in birth weight accounting for 70% of the WQS index. BPA, Triclosan, MCiNP, MEP, MEHP, MBP, PCB180 and BPS were identified as bad actors for postnatal growth accounting for 70% of the WQS index. Conclusion: Prenatal exposure to mixtures of chemicals may affect children’s pre- and postnatal growth.