Prenatal exposure to PFOS and anti-mullerian hormone concentrations in female adolescents

Abstract

TPS 632: Health effects of flame retardants and plasticizers, Johan Friso Foyer, Floor 1, August 27, 2019, 3:00 PM - 4:30 PM Background/Aim – Exposure to endocrine disrupting chemicals could have a role in dysregulating the number of follicles laid down during fetal development or in promoting depletion of the follicle pool throughout a woman’s lifespan. Circulating anti-Müllerian hormone (AMH) level appears to be a useful surrogate marker of ovarian reserve. This pilot study aimed to determine the association of prenatal exposure to perfluorooctane sulfonic acid (PFOS) with AMH serum concentrations in females at age 15. Methods – Prenatal concentrations of PFOS were measured in serum collected from pregnant mothers at enrollment (1991–1992) in the Avon Longitudinal Study of Parents and Children (ALSPAC). The median gestational age when the maternal blood sample was obtained was 16 weeks (interquartile range, 11–28 weeks). AMH concentrations were measured in serum obtained from their daughters at 15 years of age. Associations between prenatal PFOS concentrations and reproductive outcomes were estimated using linear regression models (n = 79). Results – The median PFOS concentration in the analysis group was 19.3 (25th, 75th: 15.2, 26.1). Unadjusted AMH concentrations were on average 0.47 ng/mL (95% CI: -0.87, 1.81) higher in daughters with prenatal PFOS concentrations in the middle tertile compared with daughters with prenatal PFOS in the lower tertile. Unadjusted AMH concentrations were also higher in daughters with prenatal PFOS concentrations PFOS (β = 0.93; 95% CI: -0.41, 2.29) in the higher tertile when compared to the lower tertile. Further analysis is in progress. Conclusion – An inverse association between exposure to PFOS and AMH concentrations was assumed. Preliminary results were not consistent with our initial hypothesis.