Abstract
(Anaesthesia. 2020;75:1424–1427) (Anesth Analg. 2021. doi: 10.1213/ANE.0000000000005389. Epub ahead of print) While the US Food and Drug Administration has issued a warning about the neurodevelopmental effects of anesthetic drugs in the third trimester of pregnancy and children under the age of 3, no clinical study has evaluated long-term neurodevelopmental outcomes following prenatal exposure to anesthetics. Since anesthetic drugs cross the placenta and the brain is particularly vulnerable in the prenatal period, it is plausible that prenatal anesthetic exposure could lead to adverse neurodevelopmental effects. This study examined the effects of prenatal exposure to general anesthetic agents and neuropsychological and behavioral survey scores at age 10.
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