Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years: The Hokkaido study

Abstract

IntroductionIn utero exposure to dioxin-like compounds (DLCs) may cause imbalance of immune development in early infancy. However, there are few epidemiological studies into the effects of in utero exposure to DLCs on allergies and infections during childhood. This study evaluates associations between concentrations of maternal DLCs and cord blood immunoglobulin (Ig) E, as well as allergies and infections during childhood. MethodWe recruited 514 pregnant women in a maternity hospital in Sapporo, Japan, and measured concentrations of DLCs in 426 maternal blood samples using high-resolution gas chromatography/high-resolution mass spectrometry. We examined the relationship between concentrations of maternal DLCs and cord blood IgE at birth (n=239), as well as for allergies and infections in children at 3.5 (n=327) and 7 (n=264) years, using regression analysis adjusted for confounding variables. ResultsWe found a positive association between maternal DLC concentrations and frequency of wheezing in children aged up to 7years [odds ratio (OR); 7.81 (95% confidence interval (CI), 1.42 to 42.9)]. At 3.5years, boys showed inverse associations between maternal DLC concentrations and cord blood IgE [partial regression coefficient; −0.87 (95% CI), −1.68 to −0.06], and frequency of wheezing [OR; 0.03 (95% CI), 0.00 to 0.94] but girls did not. DiscussionAs one reason for the significant association observed at 7 but absent at 3.5years, we suggest that allergic symptoms are more obvious in older children due to matured immune function. ConclusionThe findings suggest that prenatal exposure to DLCs may modify offspring immune responses and result in increased risk of allergy among children of school age.