Abstract
The intriguing story of the pathogenesis of congenital malformations is slowly. unfolding. This morning you have already heard about the biochemical and cytogenetic disorders which cause foetal disease; great interest has also been shown in the effects of maternal infections following the incrimination of rubella and cytomegalovirus as human teratogens. While it is very likely that there are infections other than rubella and cytomegalovirus involved in the causation of congenital malformations, the role of infection in human teratogenesis is not yet defined, and presents an undeniable challenge as hopefully, in this decade, relevant vaccines and chemo-therapeutic agents will be developed which will play a major part in the elimination of these embryopathies.
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