Abstract
Introduction: There are growing evidences that bisphenol A (BPA) may have adverse health effects on human. Experimental findings suggest that prenatal BPA exposure induces offspring weight gain, however, these effects are not well explored in human. We examined the effects of prenatal BPA exposure on birth weight and postnatal growth along with investigating cord blood adipokine levels, which are considered to be markers of fetal metabolic dysfunction. Methods: Cord blood BPA, leptin and total and high molecular weight (HMW) adiponectin levels were measured. Birth weight was obtained from medical record. BMI were calculated from follow-up weight/height measurements at ages 1.5, 3 and 6 year-old in the Hokkaido cohort study. In the final analysis, 285 participants were included. Results: The median concentration of cord blood BPA was 0.051ng/mL, leptin was 5.95 ng/ml and total adiponectin was 19.28 μg/ml. Cord blood BPA levels were positively associated with birth weight, BMI at 1.5, 3 and 6 year-old in boys, contrary, negatively associated in girls. We found significance in an association between BPA levels and BMI at 1.5 year-old in boys (β = 3.06; 95% CI, 0.07, 6.04). Leptin and adiponectin levels were significantly higher in girls. No association was found between cord blood BPA and leptin or adiponectin levels. Cord blood leptin and adiponectin levels were positively associated with birth weight with significance. Leptin levels were positively associated with BMI at 1.5, 3 and 6 yea-old in both sexes. Both total and HMW adiponectin levels were negatively associated with BMI at 3 year-old only in boys with significance (β = -10.37; 95% CI, -19.36, -1.38, β = -8.78; 95% CI, -15.84, -1.73, respectively). Conclusion: Prenatal exposure to BPA were not associated with cord blood leptin and adiponectin levels. The effects of prenatal BPA exposure on child growth might be potentially sex-specific.
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