Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Chien-Han Chen,Yungling Leo Lee,Wei J Chen,Ming-Hsun Wu,Pao-Jen Chen,Tien-Shan Wei,Ching-Ing Tseng

doi:10.1038/s41598-022-06951-9

Abstract

Prenatal oxidative balance might influence cord blood IgE (cIgE) levels. We aimed to explore if certain prenatal dietary sources of antioxidants and pro-oxidants are associated with cIgE elevation and if they interact with IL4 and IL13 pathway genes. A structured questionnaire was completed during the third trimester of pregnancy for 1107 full-term newborns. Surveyed antioxidant-enriched food included fish, shellfish, and fruit, whereas surveyed pro-oxidant-contained food included fried fish sticks and canned fish. Cord blood was collected for measuring cIgE levels and genotyping IL13 rs1800925, rs20541, rs848, IL4 rs2243250, and STAT6 rs324011. Fairly lean fish consumption showed protection against cIgE elevation (odds ratio [OR] 0.66; 95% CI 0.49–0.90) in the whole sample, while daily fruit (OR 0.46; 95% CI 0.27–0.79) and ≥ monthly canned fish (OR 2.81; 95% CI 1.24–6.36) exhibited associations only in genetically susceptible babies. A prenatal food protective index, comprising any fairly lean fish, daily fruit, and the absence of any canned fish, exerted dose–response protection against cIgE elevation in babies carrying the IL13 rs20541 GA or AA genotype (P for trend < 0.0001; P for interaction = 0.004). We concluded that prenatal antioxidant-enriched and pro-oxidant-contained food consumption may influence cIgE, especially in genetically susceptible babies.

Highlights

Prenatal oxidative balance might influence cord blood immunoglobulin E (IgE) levels
We further examined the canned fish of different frequencies (Table 4), and demonstrated that canned fish significantly enhanced the risk of cord blood IgE (cIgE) elevation in a dose-dependent manner for those carrying the IL13 rs1800925 CT or TT genotype (P for trend = 0.01), with a significant interaction between canned fish and IL13 rs1800925 (P for interaction = 0.02), but not for those carrying IL13 rs20541 GA or AA genotype
We evaluated certain prenatal foods with antioxidants or pro-oxidants and demonstrated their associations with cIgE elevation and their interactions with IL4-IL13 pathway genes

Summary

Introduction

We aimed to explore if certain prenatal dietary sources of antioxidants and pro-oxidants are associated with cIgE elevation and if they interact with IL4 and IL13 pathway genes. We concluded that prenatal antioxidant-enriched and pro-oxidant-contained food consumption may influence cIgE, especially in genetically susceptible babies. Some have found fish to protect against, whereas others found it to predispose to, childhood allergic d iseases[5, 9–11] Processed fish, such as fried fish sticks[12] and canned fish[13], have been demonstrated to contain pro-oxidants but rarely studied in the prenatal period. Whether the intake of various types of fish, including potential sources of antioxidants or oxidants, alters cord blood total IgE (cIgE) levels, a well-known predictor of childhood a llergy[14], remains unclear. Whether prenatal food interact with genes to influent cIgE levels remains unknown

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