Abstract
Occipitofrontal head circumference (OFC) of 172 neonates exposed prenatally to phenobarbital and phenytoin was compared to 168 control neonates, and the findings were studied in relation to a follow-up assessment of cognitive functioning in adulthood, at the University of Amsterdam, The Netherlands.
Highlights
Emphasize the frequency of conflicting results and methodological problems of studies of brain development and prenatal exposure to drugs
Neonates exposed prenatally to PB + PHT polytherapy for maternal epilepsy have smaller head sizes than neonates exposed to PB monotherapy and controls
A higher number of subjects exposed to anticonvulsants have learning problems, but these are not necessarily correlated with the head circumference at birth
Summary
Emphasize the frequency of conflicting results and methodological problems of studies of brain development and prenatal exposure to drugs. Neonates exposed prenatally to PB + PHT polytherapy for maternal epilepsy have smaller head sizes than neonates exposed to PB monotherapy and controls. A higher number of subjects exposed to anticonvulsants have learning problems, but these are not necessarily correlated with the head circumference at birth.
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