Abstract
BackgroundPrenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children.MethodsWe recruited second-trimester pregnant women between 2008 and 2011, and measured their creatinine-adjusted prenatal urine BPA levels. In 2014-2015, a subset of 4-year-old children born to these women underwent neurobehavioral assessment and physical examination. We collected urine and blood from the children and assessed social impairments, including deficits in social interaction, social communication, and other behavior patterns using the Korean version of the Social Communication Questionnaire (K-SCQ) (n = 304). We examined social impairments associated with prenatal exposure at mid-term pregnancy and postnatal exposure to BPA at 4 years of age, using linear and piecewise linear regression models.ResultsThe relationship between prenatal BPA exposure and social communication was non-linear and statistically significant at or above the flexion point for BPA levels of 3.0 μg/g creatinine in girls (58.4%, 95% confidence interval [CI], 6.5% to 135.8%). Each 2-fold increase in postnatal BPA exposure was significantly associated with an 11.8% (95% CI, 0.6% to 24.3%) increase in impairment in social communication in 4-year old girls, as indicated by the linear regression model.ConclusionPrenatal and postnatal BPA exposure is associated with social impairment at 4 years of age, particularly in girls.
Highlights
Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development
The present study examined the relationships between prenatal and postnatal BPA exposure, and social impairments in 4-year-old children; we found that prenatal exposure to BPA at or above 3.0 μg/g creatinine and postnatal exposure to BPA at 4 years of age were significantly associated with social communication impairments in girls, as measured by the Korean version of the Social Communication Questionnaire (K-SCQ)
The study has several limitations, including parent-reported questionnaires to evaluate social impairments and no participants with severe social impairments, the study makes a significant contribution to research on endocrine disruptors’ impact on children health because the relationship between BPA exposure and neurodevelopmental effects has not been fully elucidated in humans, and our results elucidate BPA exposure effects related to social impairments
Summary
Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children. The health effects of prenatal and postnatal BPA exposure are reflected in children’s behavior [12,13,14,15], and as anxiety and depression [16]. Social impairment is defined as a lack of involvement in relationships with others. It typically occurs with neurological development problems such as autism spectrum disorders (ASDs). The European Union has expressed concern regarding data [21] indicating that exposure to endocrine disruptors may contribute to neurobehavioral deficits and disease, which cost more than
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