Premorbid physical activity predicts disability progression in relapsing–remitting multiple sclerosis

Abstract

BackgroundDisability progression is a hallmark feature of multiple sclerosis (MS) that has been predicted by a variety of demographic and clinical variables and treatment with disease modifying therapies. This study examined premorbid physical activity as a predictor of change in disability over 24months in persons with relapsing–remitting MS (RRMS). Methods269 persons with RRMS completed baseline measures of demographic and clinical variables, premorbid and current physical activity, and disability status. The measure of disability was further completed every six months over the subsequent 24-month period. The data were analyzed with unconditional and conditional latent growth curve modeling (LGCM). ResultsThe unconditional LGCM indicated that there was a significant, linear increase in disability scores over time (p=.0015). The conditional LGCM indicated that premorbid physical activity significantly predicted the linear change in disability scores (standardized β=−.23, p<.005); current physical activity (standardized β=−.02, p=.81), gender (standardized β=−.06, p=.54), age (standardized β=.05, p=.56), duration of MS (standardized β=.11, p=.15), and treatment with disease modifying therapies (standardized β=−.03, p=.77) did not predict change in disability scores. ConclusionsThe current research highlights the possible role of premorbid physical activity for lessening disability progression over time in persons with RRMS. Additional research is necessary on physical activity initiated after the diagnosis of RRMS as a lifestyle approach for bolstering physiological reserve and preventing disability progression.