Abstract
<em>Objective: </em>To evaluate the outcome of human immunodeficiency virus (HIV) infected women whose pregnancies were complicated by premature rupture of membranes. <em>Methods: </em>Retrospective study conducted from January 2003 to December 2010. All HIV positive pregnant women with premature rupture of membranes (PROM) were reviewed for vertical transmission of HIV. <em>Results: </em>Of 17040 pregnant women screened for HIV infection, 67 detected HIV positive, giving a prevalence rate of 0.39%. Of 67 HIV infected women 17 pregnancies were complicated by PROM. Nine women received anti-retroviral (ARV) prophylaxis during antepartum period and three cases of vertical transmission were detected (17.6%). <em>Conclusion: </em>Our limited study suggested, antepartum antiretroviral therapy can result in a significant decline of vertical transmission. Therefore expectant management may be offered to those patients who are on ARVs and develop preterm premature rupture of membranes. DOI: <a href="http://dx.doi.org/10.4038/sljog.v33i4.4802">http://dx.doi.org/10.4038/sljog.v33i4.4802</a> <em>Sri Lanka Journal of Obstetrics and Gynaecology </em>2011; <strong>33</strong>: 150-153
Highlights
Premature rupture of membranes occurs in approximately 3% of all pregnancies accounting for nearly 1/3 of all preterm birth
Data was extracted with respect to maternal demography, prenatal care, mode of delivery, and perinatal morbidity, mortality and vertical transmission was analyzed
Of 17040 pregnant women screened for human immunodeficiency virus (HIV) infection, 67 detected HIV positive giving a prevalence rate of 0.39%
Summary
Premature rupture of membranes occurs in approximately 3% of all pregnancies accounting for nearly 1/3 of all preterm birth. Preterm premature rupture of membranes (PPROM) is a contributor to perinatal morbidity and mortality. Management of women with HIV infection who develops preterm premature rupture of membranes. (PPROM) poses an obstetric dilemma[1]. Premature rupture of membranes is a major risk factor for vertical transmission of HIV. In 1995, Minkoff et al described a significant increase in vertical transmission rate if the duration of rupture of membranes was greater than 4 hours in patients with low CD4 level[2]
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