Abstract
Despite routine suppression of endogenous gonadotropins by gonadotropin-releasing hormone (GnRH) agonists and antagonists, progesterone elevation (PE) at the time of trigger is common during controlled ovarian stimulation. Prior studies have found PE on the day of trigger to adversely affect implantation in fresh IVF cycles; however, these studies failed to capture the impact of PE in the early and mid-follicular phases. The objective of this study was to evaluate and characterize early and mid-follicular phase PE (>1.5 ng/mL) during IVF stimulation and its effects on implantation and clinical pregnancy rates in fresh IVF cycles, irrespective of the serum progesterone level on the day of trigger (TPR).
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