Premature Ovarian Insufficiency in a Popular Sample of Women in the Pribaykalsky Region: Prevalence and Age Features

Abstract

Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Objective. To determine the prevalence, clinical features and hormone characteristics of women with premature ovarian failure of different age group. Materials and methods . During the study we examined 1200 women, aged 18–45 years. Of all examined women, 17 patients with clinical and hormonal signs of POI under the age of 40 were identified. All participants signed an informed consent and underwent general clinical, instrumental and hormonal examination. Statistical analysis was performed using the Statistica 10.0. Results . The prevalence of POI among women of reproductive age was 1.4 % (1200/17). The most common clinical signs: a feeling of «heat», increased sweating and dryness in the vagina. Hot flashes were more often during the manifestation of the disease (50 %). An increase in FSH concentration was noted (26.14 ± 33.4 mIU/mL). The concentrations of thyroid hormone and prolactin were slightly higher in women aged 30–35 years, compared with older patients in the group of women at the onset of the disease in women from 35 to 40. Prolactin levels in women under 35 years old were 431.86 ± 357.82 and 387.13 ± 207.54 mU/L in the patients aged 35–40 years, accordingly (p > 0.05) Conclusion . It was established that the frequency of POF in Eastern Siberia does not differ from the frequency of occurrence of this disease in the world. The progression of clinical manifestations of hypoestrogenism occurs gradually. Hot flashes were the earliest menopausal complaints. In women aged 30–35 years, POI is accompanied by a relatively higher activity of prolactinergic and thyrotropic pituitary functions.