Abstract
Invasive fungal infections often caused by Candida species are infections which have high morbidity and mortality rates in newborn infants. 5% of the cases have also concomitant endocarditis and this causes mortality rates over 60%. Thus it has vital importance to diagnose and treat these patients with endocarditis in early stages. Most preferred treatment option is a surgical incision in addition to systemic anti-fungal therapy. Here we presented an extremely low birth weight, premature newborn with endocarditis caused by Candida tropicalis and cured solely by systemic anti-fungal treatment without the need for surgical intervention.
Highlights
Frequency of invasive fungal infection in newborns is increasing due to the reasons such as increasing number of low/extremely low birth weight newborns that are hospitalized in newborn intensive care units, increased invasive interventions, need for parenteral nutrition, use of broad-spectrum antibiotics and need for long term mechanical ventilation [1]
Endocarditis develops in 5% of invasive Candida infections and these cases have over 60% mortality rate
In this article a case of extremely low birth weight newborn with endocarditis caused by Candida tropicalis and cured by only systemic anti-fungal therapy due to high risk of mortality with surgical intervention, anticoagulant and thrombolytic treatment is presented
Summary
Frequency of invasive fungal infection in newborns is increasing due to the reasons such as increasing number of low/extremely low birth weight newborns that are hospitalized in newborn intensive care units, increased invasive interventions, need for parenteral nutrition, use of broad-spectrum antibiotics and need for long term mechanical ventilation [1]. The most common infectious agent is C. albicans These fungal infections develop severe symptoms in extremely low birth weight newborns and have mortality rates of 30% - 60% [2]. In this article a case of extremely low birth weight newborn with endocarditis caused by Candida tropicalis and cured by only systemic anti-fungal therapy due to high risk of mortality with surgical intervention, anticoagulant and thrombolytic treatment is presented. Patent Ductus Arteriosus (PDA) was found by transthoracic echocardiogram (TTE) that was performed upon detection of 2/6 grade systolic murmurs during cardiovascular system examination. Same day as yeast cell proliferation in previously collected blood culture sample was detected, abdominal catheter was removed and systemic liposomal amphotericin B therapy
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