Premature Aging in Sleep Apnea Comorbid Obesity Persons

Abstract

The goal of the work was to assess the role of pathological changes in cerebral hemodynamics in individuals with obstructive sleep apnea syndrome and its comorbid association with obesity in premature aging. Concentric–eccentric remodeling of the common carotid artery wall, the hyperconstrictor variant of cerebral angiopathy, the depletion of compensatory mechanisms of cerebral blood flow autoregulation, the restriction of hemodynamic reserve with a narrowing “corridor” of admissible changes in cerebral perfusion was established in patients with comorbid respiratory disturbances and obesity. The biological age of sleep apnea and comorbid patients exceeded the passport age by 41.3 and 49.6%, respectively. The most significant predictors of premature aging in both groups are the indicators of cerebral hemodynamics, which reflect the structural and geometric characteristics of the vessels, in particular, the thickness of the intima–media complex of the common carotid artery, as well as the indicators of microvascular reactivity. In comorbid individuals, the cerebral blood-flow index may be an additional marker of early aging. Patients with sleep apnea and obesity are characterized by accelerated rates of aging. Indicators of cerebral hemodynamics can be considered markers of premature aging.