Abstract
The cyclic decapeptide gramicidin S · 2HCl has been crystallized from an aqueous solution containing about 33% ( v v ) ethanol. The crystals are suitable for X-ray diffraction studies and are obtained reproducibly. Preliminary X-ray crystallographic studies reveal the crystal to have the orthorhombic space group C222 1(with a = 25.76, b = 35.79, and c = 38.13 A ̊ . The asymmetric unit consists of two molecules of gramicidin S · 2HCl and several molecules of solvent. This result corresponds closely to that reported by Schmidt et al. (1957, Biochem. J. 65, 744–750). A Raman spectrum of the crystal has been recorded. A strong amide I band at 1670 cm −1 and an amide III band at 1240 cm −1 indicate that gramicidin S has a β-sheet conformation in its crystal structure. An enhancement of Raman signals from gramicidin S · 2HCl adsorbed on Ag sol has been observed.
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