Abstract
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, hyperlipidemia, hyper aminoacidemia, and hypoinsulinemia that leads to a reduction in both insulin secretion and insulin action. The combination of Spirulina and Morinda citrifolia as functional supplements are emerging as important therapeutic food. This preliminary study was aimed to evaluate the hypoglycaemic and hypolipidemic effects of combining Spirulina and Morinda citrifolia to subjects with type 1 diabetes mellitus using a daily dose of 4 g/weight/day tablets for 4 months of Spirulina and 40 ml/day for Morinda citrifolia juice with standard insulin treatment in comparison with diabetic subjects receiving type 1 standard diabetes treatment, insulin injections only. Pre-intervention and post intervention fasting blood glucose levels, glycosylated haemoglobin (HbA1c) levels, and low-density lipoprotein (LDL) serum levels of the diabetic subjects were measured. Four months supplementation of combined Spirulina and Morinda citrifolia resulted in an appreciable lowering of fasting blood glucose blood serum levels. A significant reduction in the HbA1c level was also observed, indicating improved long-term glucose regulation. These findings suggest the beneficial effect of combining Spirulina with Morinda citrifolia supplements in controlling blood glucose levels and in improving components of the lipid profile of Omani subjects with type 1 diabetes mellitus.
Highlights
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both
These findings suggest the beneficial effect of combining Spirulina with Morinda citrifolia supplements in controlling blood glucose levels and in improving components of the lipid profile of Omani subjects with type 1 diabetes mellitus
Our analysis showed that after we tried on the combination of Morinda citrifolia and Spirulina to exert insulin-producing organ to secrete native insulin for glucose control, serum levels of glucose and glycosylated haemoglobin were significantly lower as compared to the pre-intervention measurement of those patients, indicating improved long-term glucose regulation
Summary
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. There are two types of diabetes, which are namely the type 1 (insulin-dependent diabetes) where the body does not produce insulin and type 2 (insulin-independent diabetes) where the body does not produce enough insulin. 90% of all cases of diabetes worldwide are type 2[1]. Diabetes is becoming a common disease in the Middle. East region as the incidence of type 1 diabetes ranges from 2.6220.18/100,000/year and the percentage of type 1 diabetes is 4.6 to 40% in the region[1]. Herbs play a big role in managing several diseases including diabetes. Examples of herbs used as anti-diabetic agents are the following, Ganoderma lucidium, Morinda citrifolia, Spirulina, Allium sativum, Eugenia jambolana, mo-
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