Abstract
The objective of this study was to evaluate the potential toxicity of methanolic extracts of Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens). Single oral dosage was administered to male mice at increasing concentrations of 100, 250,500,1000 and 2000 mg/kg body weight to assess the median LD50, which causes the death of 50% (one half) of the mice. Blood samples were collected at the end of the 14 day toxicological trial for the liver and kidney function tests. The results showed that the LD50 of P. roxburghii was 1708.3 mg/ kg body weight and of N. graveolens 1562.5 mg/kg body weight. The acute toxicity had detrimental effects on the liver and kidney function. Based on this finding, a second trial was designed, and the mice were administered day after day intragastrically one tenth (1/10) the LD50 of each plant extract for a whole month. At the termination of the 30-day trial, blood samples and organs were collected for liver and kidney function tests. The long-term administration of 1/10 the LD50 dosages had no significant adverse effects neither on the liver and kidney functions nor on the histopathological examination. In conclusion, further studies are warranted to determine the potential application of these plant as natural therapeutic products.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
