Abstract
Objective To study the preventive effect of ginsenoside Rg1 on posttraumatic stress disorder (PTSD) in mice. Methods Single prolonged stress (SPS) animal model was adopted. Mice treated with normal saline, ginsenoside (Rg1) and sertraline after stress were divided into negative control group(SPS+NS), experimental group(SPS+Rg1) and positive control group(SPS+Sertraline) respectively, and a blank control group(NS) was set. On the 8th and 10th days after modeling, the viaduct cross maze experiment and the forced swimming experiment were respectively carried out. Results In the elevated plus maze experiment, the percentage of opening times of mice in the experimental group and the negative control group [(21.11±7.21) %, (20.80±9.06) %] was significantly lower than that in the blank control group and the positive control group [(44.99±7.69) %, (39.35±14.14) %,P < 0.0001].In the forced swimming experiment, the immobility time of mice in the experimental group and the negative control group [(64.05±24.27) s, (51.23±19.76) s] was significantly higher than that in the blank control group and the positive control group [(16.85±6.90) s, (33.26±20.30) s, P < 0.001]. Conclusion The normal dose of ginsenoside Rg1 could not alleviate the anxiety and fear responses in the mice with post-traumatic stress disorder.
Highlights
Post-traumatic stress disorder (PTSD) is a delayed and long-lasting mental disorder caused by life threatening events or severe trauma
Selective serotonin reuptake inhibitor (SSRIs) is currently recognized as the first-line treatment for acute and chronic PTSD2.long-term use of SSRIs has some side effects, including abnormal reactions of the central nervous system, gastrointestinal dysfunction and sexual dysfunction3.Previous studies have shown that ginsenoside Rg1, as an important active component of ginseng, belongs to the original ginseng triol type, has no toxic and side effects, and has neuroprotective and neurotrophic effects4,5, which can promote neurogenesis6.The purpose of this study was to investigate the preventive effect of ginsenoside Rg1 on PTSD in mice
The percentage of open arm residence time in the Single prolonged stress (SPS)+NS group and the SPS+Rg1 group were significantly reduced compared with the NS group(Fig.1B; Tukey's multiple comparisons test, P
Summary
Post-traumatic stress disorder (PTSD) is a delayed and long-lasting mental disorder caused by life threatening events or severe trauma. Its symptoms mainly include pathological recurrence of traumatic events, avoidance of trauma-related clues, persistent high arousal, and emotional numbness. PTSD has multiple causes and serious harms. Selective serotonin reuptake inhibitor (SSRIs) is currently recognized as the first-line treatment for acute and chronic PTSD2.long-term use of SSRIs has some side effects, including abnormal reactions of the central nervous system, gastrointestinal dysfunction and sexual dysfunction.Previous studies have shown that ginsenoside Rg1, as an important active component of ginseng, belongs to the original ginseng triol type (see figure 1), has no toxic and side effects, and has neuroprotective and neurotrophic effects, which can promote neurogenesis.The purpose of this study was to investigate the preventive effect of ginsenoside Rg1 on PTSD in mice
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