Preliminary study on the effect of oral treatments of patients with acute myeloid leukemia before chemotherapy

Abstract

Objective To observed the effect of oral treatments before chemotherapy on the incidence and the degree of inflammation of oral mucositis of patients with acute myeloid leukemia (AML)during the chemotherapeutic period. Provide preliminary evidence for clinical effect of oral intervention before chemotherapy on patients with hematopoietic system malignant tumor. Methods Seventy-four patients with AML were divided into two groups depend on whether they want to receive oral treatments before chemotherapy. Oral treatments plus chemotherapy group received comprehensive oral examinations and treatments prechemotherapy. The chemotherapy group was not given any oral treatment. Evaluated and recorded the incidence and degree of oral mucositis. Chi square test and Mann-Whitney U were used to compare the difference between the two groups. Results The incidence of oral mucositis of the oral treatments plus chemotherapy group was less than the chemotherapy group(χ2=5.659, P=0.017), the degree of inflammation was also lower than that of the chemotherapy group(U=0, P=0). Conclusion Oral treatments before chemotherapy can reduce the incidence and the degree of inflammation of oral mucositis of patients with AML during the chemotherapeutic period. It has important clinical significance. Key words: Leukemia, myeloid, acute; Chemotherapy; Oral mucositis; Oral treatment