Abstract
Objective To investigate radiation-related human plasma metabolic features by using metabonomics method and to analyze relative metabolic pathway. Methods The plasma samples of 40 patients pre-and post-total body irradiation (TBI) from January 2012 to May 2014 were collected, and the effect of TBI on human plasma metabolites was studied by gas chromatography mass spectrometry (GC-MS), and the differential plasma metabolic features related to irradiation damage were screened. Results The levels of glucose, myristic acid, oxalic acid, 3-hydroxy butyric acid, urea, aspartic acid, valine, leucine, lysine and threonine in plasma were significantly(P<0.05) increased after TBI, while the levels of cholesterol, pyruvic acid, propionic acid, lactic acid, alanine, glycine, inositol, sorbitan, ethylene glycol and hypoxanthine were decreased drastically(P<0.05). Conclusions TBI could cause significant changes in the levels of human plasma metabolites including amino acid metabolism, glucose metabolism, lipid metabolism and so on. Key words: Total body irradiation (TBI); Radiation damage; Metabonomics; Gas chromatography-mass spectrometry (GC-MS); Plasma
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