Abstract

Tumor-associated fibroblast (tumor associated fibroblast,TAF) is an important member of the tumor interstitium.With in-depth study of the tumor microenvironment,the relationship between TAF and tumorigenesis has received increasing attention.TAF has been involved in tumor genesis,development,invasion,metastasis and angiogenesis through the secretion of various cytokines.Tumor targeted therapy for the TAF has also been gradually rising.This review reports the progress in the study on relationship between TAF and tumor development and progression. Key words: Tumor associated fibroblast; Tumor microenvironment; Tumor initiation and progression

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