Abstract
In this study, the endometriosis rats model was randomly divided into 6 groups: model control group, ovariectomized group, Gestrinone group, and quercetin high/medium/low dose group. Rats were killed after 3 weeks of administration. The expression levels of serum FSH and LH were detected by ELISA. The localizations and quantities of ERα, ERβ, and PR were detected by immunohistochemistry and western blot. The results showed that the mechanism of quercetin inhibiting the growth of ectopic endometrium on rat endometriosis model may be through the decreasing of serum FSH and LH levels and then reducing local estrogen content to make the ectopic endometrium atrophy. Quercetin can decrease the expression of ERα, ERβ, and PR in hypothalamus, pituitary, and endometrium, thereby inhibiting estrogen and progesterone binding to their receptors to play the role of antiestrogen and progesterone.
Highlights
Endometriosis (EMs) is a chronic inflammatory disease, characterized by implantation and growth of endometrial tissue outside the uterine cavity
The levels of serum follicle-stimulating hormone (FSH) in quercetin high dose group, gestrinone group, and ovariectomized group are markedly decreased compared with model control group (P < 0.05), but there was no significant difference between quercetin high dose group and gestrinone group (P > 0.05)
There was a pronounced decline on the level of serum luteinizing hormone (LH) in quercetin high and medium dose group, gestrinone group, and ovariectomized group compared with model control group (P < 0.05)
Summary
Endometriosis (EMs) is a chronic inflammatory disease, characterized by implantation and growth of endometrial tissue outside the uterine cavity It can influence pelvic environment and immune function, ovarian tissue, and follicular growth, leading to the occurrence of dysmenorrheal, infertility, menstrual disorder, and so on. To find a treatment that can inhibit the growth of ectopic endometrium and does not affect the menstrual cycle at the same time is the ideal method for the treatment of EMs. Recently, there have been many researches about quercetin, and most of them are related with estrogen correlative diseases, such as breast cancer, osteoporosis, cervical cancer, and so forth [6,7,8]. Latest studies show that quercetin can inhibit the growth of ectopic endometrium on rat EMs model [9] This is confirmed in our recent study. Estradiol benzoate was subcutaneous injected for 3 days after the operation
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