Abstract
BackgroundThe inactivation of the tumour suppressor gene and activation of the proto-oncogene are the key steps in the development of the human cancer. The p53 and c-erbB-2 are the best examples of it. In the present study, our aim was to determine the role of these genes in the carcinogenesis of gallbladder by immunohistochemistry.MethodsIn all 78 consecutive patients of gall bladder diseases were studied for p53 and c-erbB-2 expression immunohistochemically and their expression was correlated with the age, grades and stages of the disease and presence of stone. An informed consent was obtained in each case. Chi square and z test were applied to see the association of p53 and c-erbB-2 over expression with other clinicopathological factors.ResultsEight (20%) patients of gall bladder cancer were positive for p53 expression and 10 (25%) patients for c-erbB-2. The p53 positivity increased with increasing grade while cerbB-2 positivity decreased with increasing grade of gall bladder cancer. Mean age in cerbB-2 positive cases were lesser as compared to negative cases while p53 did not show such association with age.ConclusionOnly one case of gall bladder cancer co-expressed the p53 and c-erbB-2, thereby suggesting that p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer. c-erbB-2 over expression in adenoma and younger age group indicates its role as an early event in carcinogenesis of gallbladder. However study of larger sample is required to further validate the results.
Highlights
The inactivation of the tumour suppressor gene and activation of the protooncogene are the key steps in the development of the human cancer
Amongst the patients of Gallbladder cancer (GBC) none of the grade I cases over expressed p53, while 2/10 (20%) and 6/16 (37%) of grade II and III cases revealed over expression respectively
In relation to the grade of tumour 35% grade I (Figure 2b &2d), 30% of grade II (Figure 2a) and 12% of grade III (Figure 2c) GBC cases revealed c-erbB-2 over expression
Summary
The inactivation of the tumour suppressor gene and activation of the protooncogene are the key steps in the development of the human cancer. Gallbladder cancer (GBC) is a latent disease, as a result it is usually diagnosed in an advanced stage, resulting a 5 year survival rate of
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