Abstract
Objective: Pathogenesis of primary spontaneous pneumothorax (PSP) is unclear and has been rarely reported in the literature. Thus, we measured expression of Krebs Vonden Lungen-6 (KL-6), fibroblast growth factor-10 (FGF-10), and matrix metalloproteinase-9 (MMP-9) in PSP samples and evaluated their significance on the development and progress of the disease. Methods: Immunohistochemical staining and ELISA were used to measure expression of KL-6, FGF-10, and MMP-9 in the pulmonary bullae and the peripheral normal lung tissue in 24 cases of PSP. Statistical results were analyzed using the Student’s paired t-test. Results: Immunohistochemical data revealed that KL-6 and FGF10 expression in the pulmonary bullae was significantly higher than in peripheral normal lung tissue, but MMP-9 expression did not differ. ELISA confirmed that KL-6 and FGF-10 expression in the pulmonary bullae was significantly higher than the peripheral normal lung tissue (P 0.05). Conclusion: Expression of KL-6 and FGF-10 in pulmonary bullae of PSP patients was significantly higher than in the peripheral normal lung tissue, suggesting that KL-6-mediated pulmonary fibrosis and abnormal FGF-10 expression-induced congenital abnormalities in development of bronchi may be associated with PSP. MMP-9 was not different in both groups, suggesting that further correlation between MMP-9-mediated inflammation and PSP remains unclear.
Highlights
Primary spontaneous pneumothorax (PSP) refers to a fracture of the pulmonary parenchyma or visceral pleura, resulting in gas accumulation in the pleural cavity and this may be not be accompanied by underlying lung diseases [1]
matrix metalloproteinase-9 (MMP-9) expression did not differ between groups (Figures 3A,3B) MMP-9 mean concentration was 0.003± 0.003 in the experimental group and 0.001 ± 0.00 in the control group
Krebs Vonden Lungen-6 (KL-6) is a sensitive biomarker of interstitial lung diseases due to its role in pulmonary fibrosis
Summary
Primary spontaneous pneumothorax (PSP) refers to a fracture of the pulmonary parenchyma or visceral pleura, resulting in gas accumulation in the pleural cavity and this may be not be accompanied by underlying lung diseases [1]. PSP is commonly treated with emergency thoracic surgery. The PSP incidence is 7.4-18 of 10,000 persons annually for men and 1.2-6 of 10,000 persons for females [2]. PSP occurs in tall, slender individuals who are male, smoking, and have fibrosis as detected by a chest X-ray. Most PSP symptoms are mild and patients do not seek medical treatment. The actual PSP incidence may be greater than seen with clinical findings
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