Abstract
Contrast Enhanced Spectral Mammography (CESM) delivers in one single exam both morphological information and contrast uptakes of hyper-vascularized tissues in breasts, providing better diagnosis performance for breast cancer than diagnostic mammography. Contrast-Enhanced Digital Breast Tomosynthesis (CEDBT), with the association of Digital Breast Tomosynthesis (DBT), providing volumetric description of the anatomy, and CESM, providing contrast uptake information, is expected to increase localization and characterization of contrast uptakes. In this study, we introduce a new simulation method to generate mass-like enhancements from analytically defined structures. A preliminary human observer evaluation, comparing performances of CESM versus central CEDBT slices, was conducted, focusing on detectability and characterization of mass-like contrast enhancements combining different ACR BIRADS descriptors. Central CEDBT slices improve characterization of shape and margin, while CESM shows better performance in defining contrast enhancement distribution inside mass-like uptakes. Further studies are necessary to refine the benefits of CEDBT using entire sets of slices.
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