Abstract
BackgroundCumulative CT radiation damage was positively correlated with increased tumor risks. Although it has recently been known that non-radiation MRI is alternative for pulmonary imaging. There is little known about the value of MRI T1-mapping in the diagnosis of pulmonary nodules. This article aimed to investigate the value of native T1-mapping-based radiomics features in differential diagnosis of pulmonary lesions.Methods73 patients underwent 3 T-MRI examination in this prospective study. The 99 pulmonary lesions on native T1-mapping images were segmented twice by one radiologist at indicated time points utilizing the in-house semi-automated software, followed by extraction of radiomics features. The inter-class correlation coefficient (ICC) was used for analyzing intra-observer’s agreement. Dimensionality reduction and feature selection were performed via univariate analysis, and least absolute shrinkage and selection operator (LASSO) analysis. Then, the binary logical regression (LR), support vector machine (SVM) and decision tree classifiers with the input of optimal features were selected for differentiating malignant from benign lesions. The receiver operative characteristics (ROC) curve, area under the curve (AUC), sensitivity, specificity and accuracy were calculated. Z-test was used to compare differences among AUCs.Results107 features were obtained, of them, 19.5% (n = 21) had relatively good reliability (ICC ≥ 0.6). The remained 5 features (3 GLCM, 1 GLSZM and 1 shape features) by dimensionality reduction were useful. The AUC of LR was 0.82(95%CI: 0.67–0.98), with sensitivity, specificity and accuracy of 70%, 85% and 80%. The AUC of SVM was 0.82(95%CI: 0.67–0.98), with sensitivity, specificity and accuracy of 70, 85 and 80%. The AUC of decision tree was 0.69(95%CI: 0.49–0.87), with sensitivity, specificity and accuracy of 50, 85 and 73.3%.ConclusionsThe LR and SVM models using native T1-mapping-based radiomics features can differentiate pulmonary malignant from benign lesions, especially for uncertain nodules requiring long-term follow-ups.
Highlights
Lung cancer is the leading cause of cancer death in men aged ≥ 40 years and women aged ≥ 60 years, causing far more deaths than breast cancer, prostate cancer, etc
The F1 was 0.56 (Fig. 4; Table 1.). In this present study, we developed diagnostic models based on native T1-mapping images to differentiate malignant from benign lesions
The support vector machine (SVM) and logical regression (LR) classifiers both had satisfactory area under the curve (AUC) of 0.82, with sensitivity of 70%, specificity of 85% and accuracy of 80%
Summary
Lung cancer is the leading cause of cancer death in men aged ≥ 40 years and women aged ≥ 60 years, causing far more deaths than breast cancer, prostate cancer, etc. When differentiating malignancy from benign nodules, the pooled sensitivity and specificity using DWI reached 80–88 and 89–93%, respectively [13, 14]. Those MRI scans are limited by unsatisfactory repeat-ability caused by measurement bias and frequently motion artifacts, especially for nodules less than 20 mm [15, 16]. It has recently been known that non-radiation MRI is alternative for pulmonary imaging. There is little known about the value of MRI T1-mapping in the diagnosis of pulmonary nodules. This article aimed to investigate the value of native T1-mapping-based radiomics features in differential diagnosis of pulmonary lesions
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