Abstract
It has been shown that labelled human growth hormone, when injected into intact or hypophysectomized rats, accumulates in the liver and kidney (De Kretser, Catt, Burger & Smith, 1969; Mayberry, Van den Brande, Van Wyk & Waddell, 1971). McConaghey & Sledge (1970) showed that rat liver, when perfused with bovine growth hormone (BGH) in a chemically defined medium, was capable of producing ' sulphation factor'. 'Sulphation factor' (SF) is thought to be a secondary growth factor since it stimulates the proliferation of epiphysial chondrocytes and synthesis of cartilage matrix (Daughaday & Kipnis, 1966). The present communication describes similar findings when rat kidney is treated with BGH, either by perfusion in situ or by the incubation of slices in vitro. The medium used for controls, perfusions and the incubation of slices was Waymouth's MB 752/1 with 0·5% bovine serum albumin, 100 units penicillin/ml and 100 mg streptomycin/ml added. The kidneys of normal
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
