Abstract
A protein binding technique for cerebrospinal fluid (CSF) cortisol detection is described. Using this technique and a protein binding method for plasma cortisol measurement, we studied plasma and CSF cortisol in 5 children with infantile spasms (West syndrome) and in 48 children, from the neonatal period up to 14 years of age, with other diseases (in total 35 boys and 18 girls). In the infantile spasm group we found elevated cortisol levels in the plasma exceeding 260 ng/ml, and in the CSF, levels higher than 20 ng/ml. The quotient plasma cortisol to CSF cortisol was under 10.6. Similar findings were made in 15 patients with other pathologic conditions.
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