Abstract
Objective To explore mRNA expression profile variation of hepatitis B virus ( HBV)related hepatocellular carcinoma and analyze bioinformazics. Methods Long-chain RNA chip was used to inspect mRNA expression profile in HBV-related hepatocellular carcinoma and normal hepatic tissue and make GO analysis for function and cellular localization of genes with differential expression. Results By comparing mRNA expression level of liver cancer with normal control group, 991 mRNA which had more than 2 times variation and significant difference (P＜0.05 ) by statistical analysis were regarded as differential expression mRNA, accounting for 5.7% of all genes. 733 mRNA were increased by more than 2times and 258 decreased by more than 2 times; 94 increased by more than 5 times, 39 decreased by more than 5 times; 18 increased by more than 10 times, 11 decreased by more than 10 times. GO analysis revealed that differential expression mRNA involved in significant biological regulatory function, and some genes may be particular to HBV-related liver cancer. Conclusion The mRNA expression profile in HBVrelated liver cancer changes significantly, and the different genes participate in significant biological regulation process of cells and maybe participate in significant regulation process of liver cancer; HBV-related liver cancer' s expression profile has certain characteristics and something in common with liver cancers relating to other pathogenesis. Key words: Carcinoma,hepatocellular; Gene microarray; Hepatitis B virus
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