Abstract
Meeting abstracts FBP (aka Folate Receptor-a) is an immunogenic protein that is over-expressed in breast, endometrial (EC) and ovarian cancer (OC). FBP expression in malignant cells is 20-80 fold higher compared to the limited distribution in normal cells. We have completed enrollment of a Phase
Highlights
FBP is an immunogenic protein that is over-expressed in breast, endometrial (EC) and ovarian cancer (OC)
HLA-A2+ pts are enrolled into the vaccine group (VG) while HLA-A2- pts are being followed prospectively as an untreated control group (CG)
In vivo immunologic responses are assessed by both local reactions (LR) after each inoculation and delayed hypersensitivity (DTH) reactions measured at baseline (R0) and after the primary vaccine series (PVS) (R6)
Summary
FBP (aka Folate Receptor-a) is an immunogenic protein that is over-expressed in breast, endometrial (EC) and ovarian cancer (OC). FBP expression in malignant cells is 20-80 fold higher compared to the limited distribution in normal cells. We have completed enrollment of a Phase IIa clinical trial with E39, an HLA-A2 restricted, FBP peptide vaccine + GM-CSF. The vaccine is administered in the adjuvant setting to prevent recurrences in high-risk, EC and OC patients (pts) rendered clinically disease-free with standard-of-care therapy. We summarize preliminary toxicity (tox), immunologic and clinical response to vaccination
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