Abstract

Accurate and early detection of breast cancer is of high importance, as it is directly associated with the patients’ overall well-being during treatment and their chances of survival. Uncertainties in current breast imaging methods can potentially cause two main problems: (1) missing newly formed or small tumors; and (2) false alarms, which could be a source of stress for patients. A recent study at the Massachusetts General Hospital (MGH) indicates that using Digital Breast Tomosynthesis (DBT) can reduce the number of false alarms, when compared to conventional mammography. Despite the image quality enhancement DBT provides, the accurate detection of cancerous masses is still limited by low radiological contrast (about 1%) between the fibro-glandular tissue and affected tissue at X-ray frequencies. In a lower frequency region, at microwave frequencies, the contrast is comparatively higher (about 10%) between the aforementioned tissues; yet, microwave imaging suffers from low spatial resolution. This work reviews conventional X-ray breast imaging and describes the preliminary results of a novel near-field radar imaging mechatronic system (NRIMS) that can be fused with the DBT, in a co-registered fashion, to combine the advantages of both modalities. The NRIMS consists of two antipodal Vivaldi antennas, an XY positioner, and an ethanol container, all of which are particularly designed based on the DBT physical specifications. In this paper, the independent performance of the NRIMS is assessed by (1) imaging a bearing ball immersed in sunflower oil and (2) computing the heat Specific Absorption Rate (SAR) due to the electromagnetic power transmitted into the breast. The preliminary results demonstrate that the system is capable of generating images of the ball. Furthermore, the SAR results show that the system complies with the standards set for human trials. As a result, a configuration based on this design might be suitable for use in realistic clinical applications.

Highlights

  • Based on the most recent statistical report from the United States Cancer Statistics (USCS)database in 2013, breast cancer holds the highest rate of incidence among American women [1].the same study reports that after lung and bronchus cancer, breast cancer possesses the highest count of mortality among female patients

  • This paper presents a comprehensive review of the literature associated with some of the major challenges existing in conventional breast imaging systems, 2D mammography

  • To the best of our knowledge, this paper presents the first Near-field radar imaging (NRI) experimental system that can be used in a co-registered fashion with the Digital Breast Tomosynthesis (DBT) machine at the Massachusetts General Hospital (MGH)

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Summary

Introduction

Based on the most recent statistical report from the United States Cancer Statistics (USCS)database in 2013, breast cancer holds the highest rate of incidence among American women [1].the same study reports that after lung and bronchus cancer, breast cancer possesses the highest count of mortality among female patients. In the large-scale study by Lazebnik et al [70], it was found that the electrical properties discrepancy between normal tissues and malignancies can be as high as 10:1 for adipose-dominant, and as low as 10% for fibro-glandular-dominant regions in the breast. Though the latter appears to be low, it is still meaningfully higher than the contrast (1%) that has been observed in X-ray frequencies between the same types of tissues [66]. Among these, limited resolution, tissue loss, motion and heterogeneity, and difficulties in forward modeling can be mentioned [69]

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