Preliminary Research for Mutual Dose Perturbation Influence of 125I Brachytherapy Source

Abstract

For two arrangement modes of two 125I brachytheray sources, a homo-longitudinal axis and a homotransverse axis, the sum of dose distributions caused by each single source and actual dose distribution of the two coexisting sources are calculated separately in a clinically interested area by Monte Carlo simulation. Comparisons between them are used to evaluate the mutual dose perturbation influence. The result shows, for the homo-longitudinal axis arrangement, obvious perturbation can be observed along the longitudinal direction when the distances between sources' centers, L, are 0.5 cm and 1.0 cm, up to 11:7 ± 0:4% and 4:8 ± 0:2%, respectively, but, can be negligible for the distance exceeding 2.0 cm. For the homo- transverse axis arrangement, the range of dose perturbation depends on the source length and distances between sources' centers, and an influence extent is greater than the former, e.g., 27:2 ± 1:1%, 15:4 ± 0:6%, and 7:0 ± 0:3% maximum for L = 0:5 cm, 1.0 cm, and 2.0 cm, respectively. As for dose perturbation induced by the source leaning which happened in actual implant sometimes, the result indicates a dose fluctuation became more acute with obliquity increasing. The maximum dose increasing, 54:5 ± 2:1% and 199:7 ± 7:8%, and the maximum dose decreasing, 42:6 ± 1:7% and 64:9 ± 2:6%, could be observed for 10° and 30° obliquity with L = 1:0 cm for the two arrangement modes respectively.