Abstract
The fatal intravenous dose of each of the several substitutes for cocain varies enormously with differences in the rates of injection. Five or more times the fatal dose for sudden injection can be given in a period of one to two hours without causing death. The subcutaneous doses show even wider variations among the different drugs than the intravenous doses.All of the local anesthetics tested, including cocain, are mutually and quantitatively synergistic. They are all synergistic with epinephrin in its effect upon the blood pressure in a manner analogous to cocain.The systemic toxic actions of all of the members of the group are very closely alike and all cause death in cats by combined paralysis of the heart and respiratory center.Three of the members of the group-procain, stovain and apothesine-have been shown to be destroyed rapidly by the liver. All of the others are rapidly destroyed in the animal body, excepting cocain, and it seems probable that this destruction also takes place in the liver.Artif...
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