Abstract
Purpose/Objective(s): To compare seed migration rates and dosimetric parameters between intraoperatively built custom linked (IBCL) seeds and loose seeds for prostate brachytherapy. Materials/Methods: Sixty-one patients with low or intermediate prostate cancer were prospectively allocated to IBCL seed group (n Z 34) or loose seed group (n Z 27) using quasi-randomization (allocation by week of the month). Each patient underwent computed tomography and plain film radiographs 30 days after brachytherapy. Results: Seed migrations occurred more frequently in loose seed group compared to IBCL seed group (33% vs 3%; p < 0.01). IBCL seed group showed lower values compared to loose seed group (p < 0.05) in V150 (prostate volume receiving at least 150% dose; 59% vs 67%) and RV100 (rectal volume receiving at least 100% dose; 0.43 mL vs 0.75 mL). The other dosimetric parameters were not significantly different between the two groups. Conclusions: This prospective quasi-randomized control trial showed a strong trend toward a decrease in postimplant seed migration with IBCL seeds. There was a slight improvement in dosimetry of patients treated with IBCL seeds. However, overall implant quality was similar between the two groups. Author Disclosure: H. Ishiyama: None. T. Satoh: None. S. Kawakami: None. S. Komori: None. K. Tabata: None. H. Tsumura: None. A. Sekiguchi: None. I. Soda: None. M. Iwamura: None. K. Hayakawa: None.
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