Preliminary report: experience with the use of dantrolene sodium in the treatment of bites by the black widow spider Latrodectus hesperus.

Abstract

AbstractRecent experiences with the use of dantrolene sodium (Dantrium) in symptomatic envenomations by the western black widow spider (Latrodectus hesperus) are reviewed. A total of 8 patients with severe muscular pain following bites by black widow spiders were included in the study. Dantrolene sodium, a potent direct muscle relaxant, was administered both intravenously and orally to 6 patients, and 2 patients received only the oral preparation. 5 of the 6 patients given both intravenous and oral dantrolene sodium had good muscle relaxation, the results in the sixth patient being less pronounced. The 2 patients given only oral dosages had less satisfactory results. Overall, responses were more pronounced and more protracted than generally noted with the use of centrally acting muscle relaxants which are commonly used in the treatment of Latrodectus spp. envenomations. Intravenous doses generally to followed current dosing recommendations of 1 mg/kg (presently recommended as an initial intravenous dose i...