Preliminary prospective explanatory observation on the impact of 3-month steroid therapy on the objective measures of sleep-disordered breathing

Abstract

Excess endogenous steroids are a risk factor for obstructive sleep apnea (OSA). The role of exogenous steroids in this setup is not known. In this study, we prospectively looked at the consequences of a 3-month steroid treatment on the objective measures of sleep-disordered breathing. Patients scheduled for long-term steroids treatment underwent two sleep studies, the first before initiation and the second after 3months of steroid therapy. Their weight and neck girth were measured. Correlations between the changes in the body weight, neck girth, and cumulative steroids dose to apnea/hypopnea index (AHI) change were examined. A group of untreated mild OSA patients (n = 23) served as control. Seventeen patients, five males and 12 females, mean age 52.4 ± 12.6years, were studied. Fifteen patients increased their mean AHI by 56% from 9.8 ± 11.8 to 15.4 ± 15.8, p = 0.004. This increment was significantly higher when compared to the control group. Body weight and neck girth changes and cumulative steroid dose were not correlated to the AHI increment (Spearman's correlation coefficient r = 0.18 and p = 0.49, r = -0.23 and p = 0.37, r = -0.17 and p = 0.51, respectively). We found that the objective measures of sleep-disordered breathing worsened after the 3-month steroid treatment. Future studies to define pertinent mechanisms and clinical relevance are warranted.