Abstract
Radiation can lead to oxidative stress in organism. Defense against oxidative stress is important in preventing the development of diseases. This study investigated in vitro antioxidant and immunomodulation potential of Malus baccata (Linn.) Borkh., also the effectiveness of different solvent for extracting active compounds was obtained by HPLC. Of all the solvents employed, acetone extract possessed the highest amounts of total phenolic (975.7±29.2mg GAE/100g) and total flavonoids (824.9±27.7mg CE/100g), with the highest capacities for scavenging ABTS+· (136.49±1.16μmol TE/g), DPPH· (18.60±0.28μmol TE/g) and OH· (32.37±0.7mg VCE/g). The extracts all dose-dependently promoted splenocyte proliferation and inhibited splenocyte apoptosis induced by γ-radiation. HPLC analyses of the solvent extracts tentatively revealed the presence of chlorogenic acid, quercetin 3-galactoside, phloridzin and cinnamic acid. The extract could be source of natural antioxidant and immunomodulation agents for applications in functional foods.
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