Abstract
Introduction: Colon Cancer is one of leading cancer that causes morbidity and mortality worldwide, causes 774,000 deaths. Fucoxanthin contained brown seaweed Bory) extracts showed cytotoxic activity by and study, including colon cancer. This study aims to examine the absorption profile of fucoxanthin in blood plasma on colon cancer model mice. Methods: Mice were induced by azoxymethane (AOM) and two cycle dextran sulfate sodium (DSS). Mice were given an extract of brown seaweed Bory that contain fucoxanthin. Fucoxanthin content in blood plasma analyzed using mobile phase methanol: acetonitrile by Reversed- Phase High-Performance Liquid Chromatography (RP-HPLC) analysis. Results: The maximum concentration of fucoxanthin in blood was at 4 hours after administration, and the plasma concentration is 2.15 nmol/L, T1/2 6.25 h, and AUC 10.75 nmol/L/h Conclusions: The method was applied successfully in a pharmacokinetic study and the resulting oral brown seaweed bioavailability calculated.
Highlights
Colon Cancer is one of leading cancer that causes morbidity and mortality worldwide, causes 774,000 deaths
These results indicate that fucoxanthin is metabolized as fucoxanthinol, the deacetylated form, from the gastrointestinal tract into the systemic circulation in mammals
Fucoxanthin does not appear in mouse plasma after fucoxanthin administered, indicating the absence of the absorption in an animal model, fucoxanthinol, and metabolism of oral fucoxanthin
Summary
Colon Cancer is one of leading cancer that causes morbidity and mortality worldwide, causes 774,000 deaths. Fucoxanthin contained brown seaweed Bory) extracts showed cytotoxic activity by and study, including colon cancer. This study aims to examine the absorption profile of fucoxanthin in blood plasma on colon cancer model mice. Results: The maximum concentration of fucoxanthin in blood was at 4 hours after administration, and the plasma concentration is 2.15 nmol/L, T1/2 6.25 h, and AUC 10.75 nmol/L/h Conclusions: The method was applied successfully in a pharmacokinetic study and the resulting oral brown seaweed bioavailability calculated. Investigations into absorption, distribution, metabolism, and excretion of fucoxanthin suggested that fucoxanthin hydrolyzed to fucoxanthinol in the gastrointestinal tract by the liver and other digestive enzymes. Mice were administered oral fucoxanthin, and the pharmacokinetic parameters of fucoxanthin observed. This current research might provide preliminary pharmacokinetic information regarding fucoxanthin in AOM-DSS mice for future pharmacology studies
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