Abstract
The discharge patterns of phasic linear and tonic non-linear hippocampal θ-off cells and the simultaneously occurring field activity [theta (θ) and large amplitude irregular activity] were studied in response to sensory input, electrical stimulation of the dorsomedial-posterior hypothalamus and systematic administration of cholinergic agents, in urethane-anesthetized rats. Sensory input, hypothalamic stimulation and the administration of eserine all produced a total reduction of the discharges of phasic linear θ-off cells when resulting induced θ was of a frequency of 5 Hz and above. The discharges of tonic non-linear θ-off cells were totally reduced during the same conditions, even at the lowest frequencies of induced θ. Administration of atropine SO 4 abolished all θ activity previously elicited by electrical stimulation of the hypothalamus, sensory input and eserine. However, sensory input and hypothalamic stimulation still produced the reduction of discharge rates of both types of θ-off cells in the presence of atropine SO 4. The linear relation between the discharge rate of phasic linear θ-off cells and levels of hypothalamic stimulation was also preserved in the presence of atropine. It was suggested that GABA may mediate the discharge properties of hippocampal θ-off cells.
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