Preliminary observation on 32 cases of brain injury-induced acute pancreatitis in donors from donation after citizen death

Abstract

Objective To observe the diagnosis and treatment of acute pancreatitis (AP) induced by the brain trauma and cerebral stroke in donors from donation after citizen death (DCD), and maintenance of organ functions. Method The clinical data of 32 patients with different degrees of AP after brain trauma and cerebral stroke admitted by organ donation program between July 2011 and June 2015 were retrospectively analyzed. The donors with abdominal trauma and trauma after drinking were recruited. The serum amylase and lipase levels were increased in the first time, will be diagnosed as acute pancreatitis; Based on the original treatment, immediately given Ulinastatin, somatostatin and strengthen anti infection treatment; monitoring of serum amylase and lipase levels; color Doppler ultrasound examination of the pancreas; Identification of pancreatitis grading by careful investigation of the pancreatic appearances in organ procurement operation. Result 24 males and 8 females, aged from 16 to 57 years, Median- age 36 years. Cerebral stroke 13 cases, brain trauma 19 cases; Initial examination of serum amylase 440.06±144.93 U/L (normal reference value ranges from 30 to 110 U/L), serum lipase 1045.22±103.20 U/L (normal reference value 20-300 U/L); Treatment after 72h, serum amylase 120.78±40.34 U/L, serum lipase 279.63±103.20 U/L; Diagnostic accuracy of color Doppler ultrasound in acute pancreatitis was about 56%. Results from organ procurement operation: 31 cases of acute pancreatitis, 1 cases of normal appearance. Conclusion After potential donor into the donation program, routinely monitoring of pancreatitis related blood index including serum amylase and serum lipase, early diagnosis and early treatment, continuous monitoring of Results of the index to observe the effect of treatment, The condition of acute pancreatitis-induced by the brain trauma and cerebral stroke donors is not serious, they will be reversible after treatment and reduce the damage for other organs to be donated. Key words: Organ Donation; Donors; Acute Pancreatitis-induced By Brain Injury