Preliminary investigation of the genetics of ménière’s disease

Abstract

Problem: The etiology of Ménière’s disease (MD) remains obscure despite decades of research. MD likely represents a complex disorder requiring a combination of genetic and environmental factors for development. This pilot study investigated selected candidate genes for association with MD. Methods: A case-control association study was performed using single nucleotide polymorphisms (SNPs) assays within selected candidate genes. Genotypes between the 2 groups were compared via contingency tables with correction for multiple tests. Results: Genes for study were selected based on the viral theory of pathogenesis. Significant association was detected at several SNP sites though the finding is limited by the small sample size. Conclusion: A candidate gene approach using a case-control format is a feasible method for investigating the genetic aspects of Ménière’s disease. However, success is dependent on a correct theory of pathogenesis. The utility and pitfalls of genome-wide screening techniques are compared to the candidate gene approach. Significance: Contemporary molecular genetic techniques may be useful in determining pathogenesis of disorders of uncertain etiology. Support: American Otological Society