Preliminary Investigation of Doxycycline Plasma Concentrations in Cockatiels (Nymphicus hollandicus) After Administration by Injection or in Water or Feed

Abstract

Abstract Chlamydiosis is an important cause of morbidity and mortality in cockatiels (Nymphicus hollandicus); however, little published information is available regarding effective treatment options for this species. This preliminary study was conducted to determine if adequate plasma concentrations of doxycycline, the antibiotic of choice for treating chlamydiosis in pet birds, could be achieved in cockatiels by using different methods of administration. Doxycycline hyclate was administered to 5 groups comprising 3 to 6 birds each by intramuscular injection (100 mg/kg IM every 10 days for 5 injections) or by mixing with drinking water (0.28 or 0.83 mg/ml), seeds (500 mg/kg wet weight), or mash (1000 mg/kg). Three additional groups of birds received unmedicated food and water and served as controls. Plasma doxycycline concentrations were measured periodically during the 45-day trial. Birds given doxycycline by intramuscular injection had variable, localized tissue reactions and a mean trial plasma concent...