Preliminary findings of confocal laser endomicroscopy and Raman spectroscopy in human breast tissue characterisation

Abstract

Introduction: As highlighted within the ABS gap analysis, breast cancer re-excision rates for positive margin, estimated at 30% within conserving surgery, needs active research. Traditional intra-operative diagnostic techniques such as frozen section are timely, hence real time tools are necessary. We report on the diagnostic utility of probe confocal laser endomicroscopy (pCLE) and raman spectroscopy in the optical histopathological characterisation of frozen breast tissue.