Preliminary Findings in Cure of Two HAART Experienced HIV Patients by Stopping Reverse Dissemination from Bone Marrow CD4 Progenitors

Abstract

Elucidation of reverse dissemination as the true mechanism by which HIV maintains chronic infection while discounting of the generally accepted model of latent reserve can open a new frontier in research that could result in radical cure. HIV may cause and maintain chronic infection by reverse disseminating from differentiating CD4 T-lymphocyte progenitor cells (LPCs) within the bone marrow niche, and that breaking the cross-infection between older and new cells can lead to elimination of the reserve infection result in radical cure. By using a mechanism that prevents the rapid expansion of HSCs that give rise to LPCs, I collected data and information from two patients that show achievement of radical cure of HIV by absence of viral resurgence for eight months after stoppage of highly active antiretroviral therapy.