Abstract
Background Resistance to the insecticide DDT has emerged in several Anopheles gambiae populations which has stalled its use in malaria vector control programs in Nigeria. Data on insecticide resistance in Nigeria are still patchy with consequent lack of understanding of resistance mechanisms. This study was therefore designed to investigate the relationship between DDT resistance, inversion 2La and microsatellite loci in Anopheles gambiae s.s. populations from Lagos and Oyo State, South West, Nigeria.
Highlights
Resistance to the insecticide DDT has emerged in several Anopheles gambiae populations which has stalled its use in malaria vector control programs in Nigeria
Materials and methods Anopheles larvae were collected from six localities each in Lagos and Oyo State. These were reared to adults and 3-5 day old adults were exposed to 4% DDT according to the standard WHO protocol
Resistance profiles were compared between Lagos and Oyo State samples using a standard t-test
Summary
Preliminary evidence from microsatellite and 2La inversion polymorphism suggests DDT resistance drives genetic differentiation between populations of Anopheles gambiae s.s. in South West Nigeria. Adedapo O Adeogun1,2*, Kehinde OK Popoola, Lizette L Koekemoer, Basil D Brooke, Adedayo O Oduola, Samson T Awolola. From Challanges in malaria research: Core science and innovation Oxford, UK. From Challanges in malaria research: Core science and innovation Oxford, UK. 22-24 September 2014
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
