Abstract
To the Editor: “Flare” in cutaneous lupus erythematosus (CLE) is a clinically significant increase in disease activity from baseline. While quantitatively defined for systemic lupus erythematosus and used as a clinical research end point, flare has not been defined for CLE. The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) has been used to define improvement in CLE, but not worsening.1 To determine the change in CLASI activity (CLASI-A) score that corresponds to a meaningful flare in disease activity, we conducted a retrospective review of our institutional review board–approved prospective CLE database at the University of Pennsylvania.
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