Abstract

(1) Background: shape, dimension, hemodynamics, and hemocompatibility are just a few of the several challenging key points that must be addressed in designing any suitable solution for the ventricular chamber of mechanical circulatory support devices. A preliminary evaluation of different geometries of bellow-like ventricular chambers is herein proposed. The chambers were made with a polycarbonate urethane that is acknowledged to be a hemocompatible polymer. (2) Methods: an explicit dynamic computational analysis was performed. The actuation of the three chambers was simulated without the presence of an internal fluid. Maximum stress and strain values were identified, as well as the most critical regions. Geometric changes were checked during simulated motion to verify that the dimensional constraints were satisfied. (3) Results: one chamber appeared to be the best solution compared to the others, since its dimensional variations were negligible, and effective stresses and strains did not reach critical values. (4) Conclusions: the identification of the best geometric solution will allow proceeding with further experimental studies. Fluid–structure interactions and fatigue analyses were investigated.

Highlights

  • Today, research teams worldwide are engaged in the creation of a variety of innovative biomedical devices, such as the total artificial heart (TAH)

  • TAHs represent a bridge to transplant (BTT) solution, giving a significant survival chance to patients waiting for organ transplantation [5]

  • In order to compare three different configurations of an innovative ventricular chamber, numerical simulations were performed without considering fluid–structure interactions

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Summary

Introduction

Research teams worldwide are engaged in the creation of a variety of innovative biomedical devices, such as the total artificial heart (TAH). After a sequence of trials in pre-clinical models, the first TAH implantation in a human was performed in 1969 as a bridge to cardiac transplantation [2]. A third TAH has recently entered clinical trials: the CARMAT TAH, which has been implanted in patients at imminent risk of death (compassionate use) from biventricular heart failure, and who are not eligible for transplant [4]. TAHs represent a bridge to transplant (BTT) solution, giving a significant survival chance to patients waiting for organ transplantation [5]. The implantation of these devices is increasingly important, but several drawbacks still limit their wider exploitation. The dimensions of the Processes 2020, 8, 1358; doi:10.3390/pr8111358 www.mdpi.com/journal/processes

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